ApoE genotype and an apoE-mimetic peptide modify the systemic and CNS inflammatory response
نویسندگان
چکیده
منابع مشابه
Apolipoprotein E and peptide mimetics modulate inflammation by binding the SET protein and activating protein phosphatase 2A.
The molecular mechanism by which apolipoprotein E (apoE) suppresses inflammatory cytokine and NO production is unknown. Using an affinity purification approach, we found that peptide mimetics of apoE, derived from its receptor binding domain residues 130-150, bound to the SET protein, which is a potent physiological inhibitor of protein phosphatase 2A (PP2A). Both holo-apoE protein and apoE-mim...
متن کاملPolymorphisms in the Apolipoprotein E Region and Severity of Multiple Sclerosis
Background: The apolipoprotein E (APOE) polymorphism is known to affect various neurologic disorders with different effects on the immune system and CNS repair. However, previous studies on possible modulation of the clinical course of multiple sclerosis (MS) by APOE polymorphism have been inconsistent. Objective: To clarify the issue for MS patients' management and future research. Methods: Th...
متن کاملبررسی ارتباط واریاسیونهای ژنهای APOE و TNF-α با بیماری آلزایمر اسپورادیک در جمعیت ایرانی
Objectives: Several studies indicate that amyloid ß (Aß) peptide deposits and neurofibrillary tangles have key roles in pathogenesis and progression of the late-onset Alzhimer’s disease. Likewise it has been shown that inflammatory reactions play a significant role as well. Inflammatory mediators such as complement, chemokines and cytokines activators and inhibitors can releas...
متن کاملتوزیع پلیمورفیسمهای ApoE در جمعیت لر
Background: Apolipoprotein E (ApoE) contributes to susceptibility to many different kinds of diseases. The aim of this study was genotypic analysis of ApoE in the Lur population for the first time. Materials and Methods: In this study, 100 unrelated healthy Lur individuals were ApoE polymorphisms typed by polymerase chain reaction based restriction fragment length polymorphism (PCR-RFLP). Fi...
متن کاملAβ-oligomer uptake and the resulting inflammatory response in adult human astrocytes are precluded by an anti-Aβ single chain variable fragment in combination with an apoE mimetic peptide
An imbalance between production and clearance of soluble amyloid-β (Aβ) initiates the pathological process in sporadic Alzheimer's disease (AD). Aβ-specific antibodies seemed promising as therapeutic option in AD mouse models. In patients, however, vascular side-effects and Aβ-antibody complex-induced microglial and/or perivascular macrophage inflammatory responses were encountered. To prevent ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2003